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Crispr/Cas9 Technology and Cancer Therapy: A Brief Review on Therapeutic Methods and Challenges

Crispr/Cas9 Technology and Cancer Therapy: A Brief Review on Therapeutic Methods and Challenges

Abstract

Cancer genomes often harbor diverse genetic aberrations that are mainly related to carcinogenesis, cancer development, and metastasis. CRISPR/Cas9 technology is a bacterial immune system that can oppose plasmid in bacteria or exogenous viruses. CRISPR/ Cas has been used in life science studies and its application has undergone notable changes and modifications. Lately, the CRISPR/Cas9 method has been broadly utilized in cancer therapeutic investigations as it is a highly efficient method. Several studies utilized CRISPR/Cas9 to directly target potential therapeutic genes in wide range of in vitro and in vivo cancer models. Furthermore, it can likewise be applied to battle oncogenic disease, discover anti-cancer drugs, design oncolytic viruses, and modify immune cells for cancer immunotherapy. It is a strong technology for the identification of mechanisms underlying tumorigenesis and it also a promising method for cancer treatment. Here, we provide a brief overview of current preclinical CRISPR-based studies involving therapeutic targets for the inhibition of cancer cells and discuss recent advances and cha llenges in bringing CRISPR/Cas9 from the bedside to the clinic.

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